MOTS-c Mitochondrial Peptide | HPLC-Verified | Regena

MOTS-c (Mitochondrial Open Reading frame of the Twelve S rRNA-c) was identified in 2015 as one of the first peptides translated from a small open reading frame inside the mitochondrial genome. Published preclinical work has linked MOTS-c administration to improved insulin sensitivity, AMPK pathway activation, enhanced metabolic flexibility and resistance to age-related metabolic decline in rodent models.

Because the molecule sits at the interface of mitochondrial biology, longevity research and metabolic-disease modelling, MOTS-c has become a staple in laboratory panels focused on cellular energetics, mitokine signalling and exercise-mimetic pathways.

Each MOTS-c production lot is verified by an independent European peptide laboratory before any vial is released. The COA reports HPLC main-peak purity (target ≥99.0%), confirmed molecular weight by mass spectrometry, peptide content by nitrogen analysis, and a moisture figure for the lyophilised cake.

Janoshik Analytical is the default verification partner. Per-batch PDFs are published on the lab reports page and tied to the batch number printed on every vial cap.

Lyophilised MOTS-c is dispatched as a sterile white powder under inert atmosphere. Hold the unopened vial at 2–8 °C; transfer to −20 °C if the kit will not be reconstituted within 8–12 months. Reconstitute with bacteriostatic water for a two-month (60-day) in-use stability window under refrigeration.

Most laboratories use 5–10 mg/ml stock concentrations and aliquot before any freeze. Avoid vortex aggression — swirl the vial until the cake fully dissolves. MOTS-c is generally well-behaved during reconstitution; cloudy or coloured solutions are a red flag for handling error or undisclosed impurities.

Regena dispatches MOTS-c from our Germany, USA or China hub with 5–14 day tracked delivery and 5–14 day nationwide Spain coverage via tracked courier.

Every EU shipment includes the matching batch COA and a research-use customs declaration. The consultations team confirms import status for less common destinations before an order is placed.

UK research clients order from the same catalogue. Tracked dispatch from our Germany, USA or China hub typically arrives in 5–14 days; VAT and customs handling are quoted transparently at checkout.

Every UK shipment carries the same independent Janoshik COA used for EU orders. Additional documentation (MSDS, CoO, CoC) is supplied on request before dispatch.

US researchers receive MOTS-c via discreet international dispatch in temperature-buffered packaging. Transit is fully tracked end-to-end, and the COA supplied with each shipment is identical to the document EU laboratories receive.

US buyers should confirm institutional research-purchasing policy before ordering. Regena material is sold strictly for research use only.

Researchers comparing mitochondrial and metabolic peptides often place MOTS-c alongside SS-31 (Elamipretide) for inner-membrane bioenergetic work and AOD-9604 for adipose-tissue lipolysis modelling. MOTS-c sits in a distinct mechanistic lane via AICAR-like AMPK activation; SS-31 modulates cardiolipin interaction at the inner mitochondrial membrane; AOD-9604 acts on β3-adrenergic fat-mobilisation pathways.

Stocking all three from the same supplier keeps batch documentation and packaging consistent across a comparative panel.

An honest MOTS-c supplier publishes a per-batch third-party COA, names the testing laboratory and prints the batch number on the vial. Reject suppliers showing a single static COA across all production runs or refusing to identify their analytical partner — those are reliable indicators of unverified material.

Regena's consultations team is happy to walk a new buyer through the COA, the reconstitution maths and the storage plan before any order is dispatched.