Longevity · Research kit
MOTS-c
4.9· 8 reviews
Mitochondrial-derived peptide used in exercise-mimetic and AMPK research.
- Class
- Mitochondrial-derived peptide (16 aa)
- Half-life
- Short
- Kit
- 10 vials
- Use
- Research only
Kit of 10 vials · 40mg per vial
Best value€419.00
€41.90 per vial · ≈ €0.09/day for ~480 days · €1.05/mg
Sold as 10-vial kits · minimum order
We don't sell single vials. Every order is a sealed 10-vial research kit — it's how serious labs and long-protocol researchers actually buy, and it's how we keep quality and price honest.
- ✓ Lower €/mg — batching 10 vials cuts our fill cost, and we pass it to you (per-vial price is 40–60% lower than typical single-vial pricing).
- ✓ One batch, one COA — all 10 vials come from the same HPLC-verified lot, so your data stays consistent across a full study.
- ✓ Real supply for real protocols — a 10-vial kit covers ~30–90 days of research depending on dose, so you're not re-ordering mid-study.
- ✓ One shipment, one customs pass — fewer parcels = lower risk, lower shipping cost per vial, faster to your bench.
Choose strength · 10 vials per kit
Bulk kit pricing
- 2+ kitssave 5%
- 3+ kitssave 10%
- 5+ kitssave 15%
Auto-applied at checkout. Stack sizes across the cart.
- HPLC ≥99%COA per batch
- Ships in 24hTracked, discreet
- Free re-shipIf lost or seized
Rilz26 at checkout — free 6-month support + 30 peptide guides
Secure bank-transfer checkout · IBAN provided instantly · Ships from Spain within 24h
€ Price per mg — honest breakdown
Every MOTS-c kit ships as 10 vials. Here's the exact maths so you can see which strength gives you the most peptide per euro. Larger kits are usually significantly cheaper per mg.
Kit price
€419.00
40 mg × 10 vials
Per vial
€41.90
€419.00 ÷ 10 vials
Total mg in kit
400 mg
40 mg × 10
Per mg
€1.05
€419.00 ÷ 400 mg
Compare every kit
| Kit | Kit price | Per vial | Per mg |
|---|---|---|---|
| 10 mg / vial | €279.00 | €27.90 | €2.79 |
| 40 mg / vialBest €/mg | €419.00 | €41.90 | €1.05 |
What is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region. Research describes AMPK activation and modulation of the folate/methionine cycle in exercise-mimetic models.
Mechanism of action
Activates AMPK and modulates folate/methionine cycle.
Primary research areas
Metabolic flexibility, exercise mimetic studies.
Research notes
- Encoded within mitochondrial DNA, distinguishing it from nuclear-encoded peptides.
MOTS-c: expanded research context
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. It is one of a small family of mitochondrial peptides (with humanin and SHLPs) that appear to signal in an endocrine-like manner about mitochondrial metabolic state. Research interest centres on AMPK activation, glucose homeostasis and exercise-mimetic pathways.
In preclinical work, MOTS-c improved insulin sensitivity, protected against age-related insulin resistance and enhanced physical capacity in aged mice. Circulating levels decline with age in humans. Published proteomic work links MOTS-c to skeletal-muscle metabolic adaptation and exercise-response gene programmes.
Published clinical evidence
Selected peer-reviewed studies and outcome trials referenced in the MOTS-c literature. Sources listed for orientation; full papers via PubMed / journal DOI.
MOTS-c improves insulin sensitivity (mouse)
Cell Metabolism · 2015 (Lee et al.)
Original characterisation of MOTS-c — systemic administration prevented diet-induced obesity and improved insulin sensitivity via AMPK activation in a rodent model.
MOTS-c enhances physical capacity in aged mice
Nature Communications · 2021
Late-life MOTS-c administration improved treadmill capacity, grip strength and metabolic markers in aged mice.
Circulating MOTS-c and age in humans
Journal of Gerontology · 2019
Cross-sectional human data showing progressive decline of circulating MOTS-c with chronological age.
MOTS-c and skeletal-muscle exercise adaptation
American Journal of Physiology · 2020
MOTS-c expression rose in response to acute exercise and modulated muscle transcriptional programmes for metabolic adaptation.
Verified test batches — download COAs
Independent third-party Certificates of Analysis for recent MOTS-c batches. Click any COA to open or download the full lab report — verify each result at www.janoshik.com/verify.
Verify any COA at www.janoshik.com/verify using the unique key printed on the report.
Why researchers buy from Regena
HPLC ≥99% purity
Every batch independently tested. Mass spectrometry verification on every research compound. COAs on request.
10-vial kits, properly sealed
Lyophilized peptide, rubber-stoppered amber vials, batch-coded. Stable for shipping; cold storage on arrival.
Ships from Spain, EU-wide
Tracked delivery 2–5 working days across the EU. Discreet, plain packaging. UK & worldwide options.
Secure SEPA bank transfer
Encrypted checkout, verified IBAN. No card details stored. Card payment links available on request.
How ordering works
- 1
Pick your MOTS-c kit above
Each kit contains 10 vials. Choose your strength — bigger vials give you a lower €/mg.
- 2
Secure checkout in under 2 minutes
Add to cart, fill in shipping, get your IBAN and order reference instantly.
- 3
Pay by bank transfer (or card on request)
Bank transfer is fastest and fee-free. Need a card? Message us on WhatsApp and we'll send a payment link.
- 4
We ship within 24 hours
You get a tracking number by email + WhatsApp. EU delivery 2–5 working days. COA included on request.
Frequently asked questions
Research-use disclaimer
Information on this page is provided for educational and scientific reference purposes only. MOTS-c is a research compound intended for in-vitro laboratory investigation by qualified professionals. Nothing here constitutes medical advice, dosing guidance or a recommendation for human or veterinary use. Half-life and mechanism descriptions reflect published literature approximations.
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Free download · PDF
Free: Peptide Storage & Reconstitution Guide
30-page PDF — vial handling, sterile reconstitution, dosing math, cold-chain storage. Plus a daily research insight email from the lab.
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Affiliate program · 20% commission
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Apply to become an affiliateMOTS-c — shipped to research hubs worldwide
Same HPLC-verified MOTS-c batch, same COA — tracked delivery to laboratories and independent researchers across Europe, the UK, the USA and beyond. Pick a hub for local shipping window and currency notes.
- MOTS-c for Jaén researchers
- MOTS-c for Leeds researchers
- MOTS-c for Liverpool researchers
- MOTS-c for Louisiana researchers
- MOTS-c for Malta researchers
- MOTS-c for Michigan researchers
- MOTS-c for Minnesota researchers
- MOTS-c for Murcia researchers
- MOTS-c for New Mexico researchers
- MOTS-c for North Dakota researchers
- MOTS-c for Ohio researchers
- MOTS-c for Oxford researchers
- MOTS-c for Philadelphia researchers
- MOTS-c for Portsmouth researchers
- MOTS-c for Romania researchers
- MOTS-c for San Francisco researchers
- MOTS-c for Seattle researchers
- MOTS-c for South Carolina researchers
- MOTS-c for Stoke-on-Trent researchers
- MOTS-c for Tarragona researchers
- MOTS-c for the United Kingdom researchers
- MOTS-c for Valencia researchers
- MOTS-c for Virginia researchers
- MOTS-c for Wisconsin researchers
Customer reviews
What researchers say about MOTS-c
- Verified
COA matched batch number exactly
Ordered three batches of BPC-157 over four months. Each shipment arrived cold-packed with a COA and the batch numbers cross-checked against the public testing database. Purity reported between 98.7% and 99.2% — consistent with what we measured in-house by HPLC.
Dr. M. AnderssonStockholm, Sweden - Verified
Fast UK delivery, clean reconstitution
Discreet packaging, arrived in 48 hours to London. Lyophilised cake was firm, dissolved completely in bac water with no cloudiness. Dose math in IU on the calculator made repeat dosing trivial.
J. WhitmoreLondon, UK - Verified
Best documentation I've seen from a supplier
We compared three suppliers as part of a sourcing audit. Regena was the only one with chromatograms, retention times and lab-named COAs published per batch. That's the standard the rest of the industry should meet.
Prof. L. RomanoMilan, Italy - Verified
Good product, customs took an extra day
Product itself is excellent — clean reconstitution, COA available. Customs added 24 hours which is outside Regena's control. Support replied within an hour when I asked for an update.
K. PetersenCopenhagen, Denmark - Verified
Independent lab agreed with stated purity
We sent a sub-sample to an independent lab. Their result was within 0.4% of the published Regena COA. That's a level of transparency you almost never see in research-peptide sourcing.
Dr. S. PatelBirmingham, UK - Verified
Cold chain held the whole way
Temperature indicator strip in the package stayed in the green. Vials still chilled on arrival despite a 3-day route. Whoever packs these boxes knows what they're doing.
A. MüllerBerlin, Germany
Share your experience
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Cite this reference
Researching MOTS-c?
Copy a ready-made citation or HTML link. Backlinks from research blogs, lab wikis and biohacker communities help others find verified peptide sources.
Regena Peptides. (2026-07-18). MOTS-c — HPLC-verified research peptide. https://www.regena-peptides.com/peptides/mots-c
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